The cat is called Nomi, a 3-year-old Ragdoll cat. This cat developed a high fever with a body temperature of 40.2°C, lost its appetite, had a severely swollen belly, and had very prominent ascites inside. Its hind limbs also experienced spasms. After PCR testing, it was confirmed that it had neurogenic wet infectious peritonitis. Within two weeks, Noomi’s weight dropped from 4.5 kilograms to 2.7 kilograms, a loss of 1.8 kilograms. The local veterinarian assessed that its prognosis was very poor.
The mortality rate of feline infectious peritonitis is very high. Once a cat is infected with this disease, it is very difficult to cure. Traditional treatment methods have no effect either. Nomi has very rapid breathing, breathing 50 times per minute, and also suffers from severe jaundice. Its albumin/globulin ratio is 0.2, which is far lower than the normal ≥0.8. It also experienced nerve damage and immune system failure.
Nomi’s shop owner tried home remedies, which involved traditional Chinese medicine combined with hormones, to help Nomi. However, its condition worsened. It began to vomit and become dehydrated. The veterinarian said that if Nomi was not given targeted treatment, it would have survived for less than seven days and its nerve damage would be irreversible.
The treatment plan is as follows: The core treatment adopts GS-441524 targeted antiviral therapy. The entire course of treatment lasts for 84 days. The dosage is calculated based on Nomi’s weight of 2.7 kilograms. In the first 42 days, it needs to be subcutaneously injected at a dose of 18 mg/kg every day. In the following 42 days, the daily subcutaneous injection dose is adjusted to 15mg /kg. At the same time, for supportive treatment, it is necessary to infuse albumin, use diuretics and B vitamins, and also supplement it with nerve growth factors. In addition, for monitoring, the veterinarian will check its blood routine, biochemical indicators, viral load every 14 days, and also observe the changes in its neurological symptoms.
Nomi’s recovery was as follows: From the 1st to the 7th day, Nomi’s high fever dropped to 38.8°C, the ascites in its abdomen no longer increased, and the frequency of its epileptic seizures also decreased. On the 14th day, its albumin/globulin ratio rose to 0.3, edema decreased by 20%, and it could eat a small amount of food by itself. On the 28th day, edema reduced by 50%, jaundice disappeared, its albumin/globulin ratio reached 0.5, epilepsy completely stopped, and its weight was 3 kilograms. On the 42nd day, edema completely subsided. Its albumin/globulin ratio rose to 0.7, and its weight reached 3.5 kilograms. The overall situation has improved significantly. On the 63rd day, jaundice did not recur. Its albumin/globulin ratio returned to normal at 0.8, and its weight was 3.9 kg. It could move and play normally. On the 84th day, the albumin/globulin ratio stabilized at 1.0, all symptoms disappeared, and its weight returned to 4.3 kg. It achieved clinical cure.
Judging from the results and data, Noome’s survival time far exceeded the expected 7 days. During the 12-month follow-up, there was no recurrence. Its neurological function also fully recovered. In terms of indicators, the albumin/globulin ratio rose from 0.2 to 1.0, bilirubin dropped from 68µmol/L to 10µmol/L, and its viral load turned negative. In terms of quality of life, Nomi’s weight has returned to 95% of its initial weight, and its appetite and reactions have both returned to normal.
Nomi’s owner proved that at first, the veterinarian had no hope for Nomi, but after four weeks of treatment, Nomi was finally able to eat and walk again. These 84 days of persistence were really well worth it! Now Nomi is full of energy and as vigorous as before. The owner was extremely grateful for this medicine. It was it that gave Nomi a second life.
